Can a profile have multiple page layouts?
Yes, a profile can have access to more than one layout - however there can be only one default layout for a profile.
To manage layout assignment
- Go to Settings > Setup > Modules and Fields > Layout.
- Click the Layout Assignment button.
- In the Layout Assignment popup, assign layouts to each profile and select the default profile for each layout.
For example, here, the profile Sales managers has access to 3 layouts, but only one layout can be set as the default layout for the profile - in this case, Mobile Sales. 
This means that the users under the Sales managers profile can access all the three layouts but if they create records using the CRM mobile app, the records will be pushed to the Mobile Sales layout by default.
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